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The solution lies in The very fact there are multiple isoforms of every troponin subunit that are encoded by distinct genes, several of which can be expressed selectively in cardiac muscle. Whilst TnI and TnT have unique cardiac and skeletal isoforms, they share a common isoform of TnC: the slow-twitch skeletal muscle isoform (ssTnC) (Upper body ag… Read More

The differences in AA sequences permitted improvement of quantitative assays for cTnI/T. Most cTn assays are non-competitive enzyme-joined immunosorbent assays (ELISA) according to the sandwich principle, utilizing the large specificity and affinity of antibodies.31 The assay is based with a seize antibody which binds to a specific epitope of cTn, … Read More

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